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A cell thatleaves the cycle in the Gi phase usually begins terminal differ-entiation by entering the Go phase (“O”stands for “outside”the cycle). While noncancereffects tend to develop almost immediately or very soonafter a toxic dose is received, cancer may not develop untilan interval of 20 years or more has elapsed. Granulocytes partially degranulate during interac-tion with the implant . At the entry to the duodenum, the common bile duct is joined bythe main pancreatic duct to form the hepatopancreatic ampulla (ofVater),and together they enter the second part ofthe duodenum.
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